Technology Bundle ID: TAB-2938

Monoclonal Antibodies to the HIV-1 Core Protein p24

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Licensing Contact:
Primary Inventors: 
Timothy Granade (CDC)
Co-Inventors: 
Chou-Pong Pau (CDC), Dennis Bagarozzi (CDC), Jason Goldstein (CDC), Sherry Owen (CDC), Shon Nguyen (CDC), Susan Wells (CDC)
Development Stage: 
Prototype
Development Status: 
  • In vitro data available
  • Prototype
Institute or Center: 
CDC

The core proteins of HIV-1 are secreted into the environment during replication in the human body. The detection of the core protein p24 (molecular mass of 24 kilodaltons) serves as an indicator of early HIV-1 infection, and assays detecting it have been available since the late 1980s. However, the development of a rapid assay for the detection of HIV-1 p24 has only recently become available. Monoclonal antibodies developed in our laboratory for research and development of a rapid HIV-1 p24 assay would provide large quantities of material at a much lower price than could be obtained in the commercial market.

Applications:
  • Diagnostic assay for the detection of HIV-1
  • Research tool used to study HIV-1
Advantages:
  • Inexpensive antibodies to HIV-1 core proteins
  • Larger source of HIV-1 monoclonal antibodies

Patents

EIR Application

Research Tool - Patent protection is not being pursued for this technology.

Publications

Ly TD, et al.
PMID 15542143
Miles SA, et al.
PMID 8419814
Schupbach J, Boni J.
PMID 8366170
Weber B, et al.
PMID 9665998
Workman S, et al.
PMID 19482361

Updated

May 19, 2015

Data Source: 
tts