Technology Bundle ID: TAB-2904

Whole Animal Feeding Flat (WAFFL): A High-throughput Platform for the Automated Handling of Flies

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Primary Inventors: 
Maria De Los Angeles Jaime (NIDDK)
Co-Inventors: 
Brian Oliver (NIDDK)
Development Stage: 
Prototype
Development Status: 
  • Early stage
  • Prototype
Institute or Center: 
NIDDK

Drosophila is well-suited organism to be use in high-throughput studies due to their short, defined life cycle and genetic tools. However, current high-throughput fly methodologies are not ideal. They can require a significant amount of fly manipulation, the use of anesthetics, and a large quantity of drug or materials.

Inventors at the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health have developed an elegant solution. This 96-well system called the Whole Animal Feeding Flat (WAFFL) enables the housing and feeding of flies while reducing the number of manipulations. The WAFFL system is comprised of four main units: (1) Food Reservoir, (2) Feeder (housing), (3) Receiver and (4) Transfer Adapter and is compatible with standard laboratory equipment. The system has been validated for reliability and reproducibility of study results.

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Applications:
  • In vivo high-throughput screening
  • Automated drug research in small model organisms
Advantages:
  • Minimal fly handling facilitates multiple treatments
  • Less food required (and therefore, less drug!)
  • Allows for testing a single fly per well (96 options in one plate)
  • Compatible with standard (96 well) equipment and automation robots

Patents

PCT Application PCT/US2015/060575
Filed on 2015-11-13
US Application 15/526,672
Filed on 2017-05-12
US Application 62/080,181
Filed on 2014-11-14

Various international applications pending

Updated

Apr 18, 2017

Data Source: 
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