Technology Bundle ID: TAB-2824

Improved Acoustic Plethysmograph System for Noninvasive Measurement of Pulmonary Function

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Primary Inventors: 
Jeffrey Reynolds (CDC)
Co-Inventors: 
David Frazer (CDC)
Development Stage: 
Prototype
Development Status: 
  • In vivo data available (animal)
  • In situ data available (on-site)
  • Prototype
    Institute or Center: 
    CDC

    CDC researchers have developed a novel acoustic whole body plethysmograph (AWBP) that allows measurement of tidal volume in lab animals, independent of gas compression in the lung. This system provides particular advantages over the traditional whole body plethysmograph (WBP) when measuring model animals with increased gas compression due to increased airway resistance or increased acceleration in the breathing pattern.

    Measurement of tidal volume in conscious, unrestrained mice has traditionally been performed using WBP. An animal is placed in a chamber where pressure changes due to respiration are observed, which are then related to tidal volume. Although the effects of gas compression on the WBP signal of normal mice may be negligible, gas compression in mice with altered breathing pattern and/or increased airway resistance can produce significant errors in the measurement of tidal volume. A major advantage of this novel AWBP technology is the ability to measure the tidal volume signal independent of gas compression. This is particularly useful when measuring mice that have been exposed to a respiratory irritant or toxin that increases airway resistance or the frequency content of the breathing pattern. Further, with slight hardware and software modifications the system may also be used to measure specific airway resistances.

    Applications:
    • Measurement of tidal volume, respiratory rate, and other breath rate parameters of laboratory animals
    • Research and animal modeling tool for in vivo pulmonary investigations of therapeutics efficacy and studying certain infectious diseases
    • Particularly useful when measuring animals exposed to a respiratory irritant or toxin that increases either airway resistance or the frequency
    • Noninvasive measurement of specific airway resistance and restrictions in an unrestrained animal
    Advantages:
    • System allows fast, efficient, noninvasive measurement of lab animal pulmonary function for numerous inhalation, toxicology research studies
    • Measures tidal volume signal independent of gas compression, increasing accuracy when gathering data from animals with altered breathing patterns and/or elevated airway resistance
    • System operates at a fixed frequency, and automatically tracks the change in sound amplitude as a function of time due to change in lung volume

    Patents

    US Application 60/958,537
    Filed on 2007-07-06
    US Pat 8,328,729

    Issued 2012-12-11

    Publications

    Daubenspeck JA , et al.
    PMID 17962574
    Reynolds JS, et al.
    PMID 16897419
    Reynolds JS, et al.
    PMID 18450981

    Updated

    May 27, 2014

    Data Source: 
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