Technology Bundle ID: TAB-2792

Human Influenza Virus Real-time RT-PCR: Detection and Discrimination of Influenza A (H3N2) Variant from Seasonal Influenza A (H3N2) Viruses, Including H3v and Seasonal H3 Assays

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Primary Inventors: 
Bo Shu (CDC), Stephen Lindstrom (CDC)
Kai-Hui Wu (CDC), LaShondra Berman (CDC)
Development Stage: 
Pre-Clinical (in vitro)
Development Status: 

In vitro data available

Institute or Center: 

This invention relates to methods of rapidly detecting influenza, including differentiating between type and subtype. CDC researchers have developed a rapid, accurate, real-time RT-PCR assay that has several advantages over culture and serological tests, which require 5 to 14 days for completion; this assay can also be easily implemented in kit form. To date, hundreds of human cases of infection with the H3N2 variant virus have been confirmed. The increased numbers of human infection of H3N2 variant virus has led to a need for a highly sensitive and specific assay for the diagnosis and confirmation of the H3N2 variant virus.

  • Influenza diagnostic using clinical specimens
  • High-throughput sample screening
  • Government, regional influenza surveillance programs
  • Especially useful for H3N2 screening
  • Sensitive detection
  • Specific discrimination of influenza subtypes
  • Easily formatted as kit or array
  • Faster than culturing and serological identification methods
  • Less laborious and more objective than immunoassays


PCT Application PCT/US2014/061802
Filed on 2014-10-22
US Application 15/989,924
Filed on 2018-05-25
US Application 61/894,291
Filed on 2013-10-22
US Pat 10,006,097

Issued 2018-06-26


Cox CM, et al.
PMID 21749798
Jhung MA, et al.
PMID 24065322
Lindstrom S, et al.
PMID 22516540


Mar 18, 2014

Data Source: