Technology Bundle ID: TAB-2789

Computer Controlled Aerosol Generator with Multi-Walled Carbon Nanotube Inhalation Testing Capabilities

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Licensing Contact:
Primary Inventors: 
Walter McKinney (CDC)
Co-Inventors: 
Bean Chen (CDC), David Frazer (CDC)
Development Stage: 
Prototype
Development Status: 
  • In vitro data available
  • In vivo data available (animal)
  • In situ data available (on-site)
  • Prototype
Institute or Center: 
CDC

This invention pertains to a CDC developed sonic aerosol generator that provides a controllable, stable concentration of particulate aerosol over a long period of time for aerosol exposure studies. Specifically, in situ testing data indicate uniform aerosol stability can be maintainable for greater than 30 hours at concentrations of 15 mg/m3 or more. Additionally, the technology was specifically developed for, and validated in, animal studies assessing exposure to airborne multi-walled carbon nanotubes (MWCNT). It has been suggested that workers may be at risk for exposure to nanosized particles during the manufacture, handling, and cleanup of engineered nanomaterials. Compared to other technologies, this CDC aerosol generator is particularly helpful when used for generating high testing concentrations of MWCNT aerosols that more accurately represent particulate levels that may be seen in a workplace environment.

Applications:
  • Studying the size and shape of the aerosolized particles produced from simple vibrations of bulk material
  • Toxicological investigations and risk assessment of aerosol exposures, especially those related to nanoparticle manufacturing
  • Any aerosolization application where the aggregating “bird's nest” tendencies of airborne multi-walled carbon nanotubes must be overcome
Advantages:
  • Fully automated system with integrated feedback control for optimized stability in testing
  • Maintains concentration of aerosols for >30 hours at concentrations of 15 mg/cubic meter or more
  • Capable of generating high concentrations of aerosols that more accurately represent the levels seen in a workplace environment
  • System insures that each run produces a constant particle concentration, air flow, pressure, temperature and humidity within a testing chamber

Patents

US Application 14/473,324
Filed on 2014-08-29
US Application 61/237,945
Filed on 2009-08-28
US Pat 8,875,702

Issued 2014-11-04

Publications

Chen BT, et al.
PMID 23033994
McKinney W, et al.
PMID 19555230
Porter DW, et al.
PMID 19857541
Porter DW, et al.
PMID 22881873

Updated

Mar 7, 2014

Data Source: 
tts