Technology Bundle ID: TAB-2785

Rabies Vaccine for the Oral Immunization of Domesticated Animals, Wildlife and Feral Animals

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Licensing Contact:
Co-Inventors: 
Charles Rupprecht (CDC)
Development Stage: 
Pre-clinical (in vivo)
Development Status: 
  • In vitro data available
  • In vivo data available (animal)
Institute or Center: 
CDC

This invention, developed by the CDC and collaborators, entails a live, attenuated recombinant rabies virus vaccine that can elicit an effective anti-rabies immune response in animal recipients. Inoculation with a live, attenuated, rabies virus allows for the optimized production of immunity in the absence of pathogenicity. Oral administration of rabies vaccines is often a preferred route of vaccine delivery because it is most effective in wildlife. Unfortunately, availability of an oral vaccine for canines has been a significant hurdle to date.

This vaccine technology could be used for immunization of stray dogs by an oral route. In developing nations, more than 90% of human exposure events and 99% of human deaths due to rabies are caused by rabid dogs. Using this vaccine with a broadly implemented oral vaccination strategy provides a promising opportunity for reducing transmission of rabies between stray dogs and, thereby, increasing protection for people.

Applications:
  • Wildlife and humane shelter rabies prevention and control programs
  • Improved rabies vaccines for pets and livestock
  • Humane, targeted approach to elimination of rabies reservoirs in feral animal populations
Advantages:
  • Safe and effective
  • Oral immunization is the most practical and efficient method of rabies vaccination of wildlife and feral animals
  • Vaccine has demonstrated protection in vivo
  • Recombinant, non-neuroinvasive virus expressing a neuroinvasive glycoprotein and/or pro-apoptotis gene safely induces a robust and desirable immunological response

Patents

PCT Application PCT/US2001/009529
Filed on 2001-03-23
US Application 11/174,796
Filed on 2005-07-05
US Application 60/191,510
Filed on 2000-03-23
US Pat 7,074,413

Issued 2006-07-11

Publications

Morimoto K, et al.
PMID 11348722

Updated

Mar 7, 2014

Data Source: 
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