Technology Bundle ID: TAB-2768

Recombinant Polypeptides for Clinical Detection of Taenia solium and Diagnosis of Cysticercosis

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Licensing Contact:
Primary Inventors: 
Victor Tsang (CDC)
Co-Inventors: 
Kathy Hancock (CDC), Patricia Wilkins (CDC), Ryan Greene (CDC)
Development Stage: 
Pre-Clinical (in vitro)
Development Status: 

In vitro data available

Institute or Center: 
CDC

CDC scientists have developed synthetic/recombinant polypeptides that can be used for the creation of inexpensive, high-quality cysticercosis diagnostic assays. Taenia solium is a species of pathogenic tapeworm. Intestinal infection with this parasite is referred to as taeniasis and it is acquired by ingestion of T. solium cysticerci found in raw and undercooked pork, or food contaminated with human or porcine excrement. Many infections are asymptomatic, but infection may be characterized by insomnia, anorexia, abdominal pain and weight loss. Cysticercosis is the formation of cysticerci in various body tissues resulting from the migration of the T. solium larvae out of the intestine. Although infection with T. solium is itself not dangerous, cysticercosis can be fatal. In the present invention, specific antigen encoding nucleotide sequences have been cloned; assays based on the produced antigens may be useful for improvements over the existing Western blot diagnostic method for identifying individuals with cysticercosis. Additionally, these polypeptides may have applications in developing vaccines and therapeutics to prevent taeniasis.

Applications:
  • Diagnosis of T. solium infection and confirmation of cysticercosis
  • Zoonotic disease research and surveillance
  • Public health monitoring programs
  • Livestock health and food-source monitoring
  • Therapeutics/vaccine development
Advantages:
  • May provide a rapid, accurate, sensitive and safe alternative to current radiologic, Western blot and biopsy diagnostic methods
  • Can be easily formatted as a simple-to-use assay kit for FAST-ELISA
  • Cost-effective, and quite useful for developing regions of the world

Patents

PCT Application PCT/US2001/010392
Filed on 2001-03-30
US Application 60/194,148
Filed on 2000-04-04
US Pat 7,094,576

Issued 2006-08-22
US Pat 7,595,059

Issued 2009-09-29

Publications

Greene RM, et al.
PMID 11128471

Updated

Feb 6, 2014

Data Source: 
tts