Technology Bundle ID: TAB-2767

Methods for the Simultaneous Detection of Multiple Analytes

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Primary Inventors: 
Joseph Martinez (CDC)
Co-Inventors: 
George Carlone (CDC)
Development Stage: 
Pre-Clinical (in vitro)
Development Status: 

In vitro data available

Institute or Center: 
CDC

CDC researchers have developed a method of simultaneously detecting and distinguishing multiple antigens within a biological sample. Epidemiological and vaccine studies require species serotype identification. Current methods of serotyping are labor intensive and can easily give subjective, errant results. This technology utilizes serotype specific antibodies bound to fluorescent beads, allowing for simultaneous single tube capture and detection of multiple antigens in one rapid, high-throughput flow cytometry assay. Such technology has an extremely wide range of useful applications, including but not limited to complex serotyping investigations for vaccine development and formulation, as a tool for rapid clinical prognosis or diagnosis, and the assay can be formatted as a kit for any number of laboratory research uses.

Applications:
  • Complex serotyping and/or multi-antigen composition investigations
  • Tool for clinical diagnosis or prognosis of a disease or infection
  • Tool for basic research
Advantages:
  • Rapid flow cytometry assay
  • Simultaneous detection of multiple different antigens and antibodies
  • Excellent for high-throughput usage
  • Provides a reliable, reproducible measurements of serotype-specific antigens within a sample
  • Technology particularly well-developed for addressing S. pneumoniae serotyping concerns

Patents

PCT Application PCT/US2001/009576
Filed on 2001-03-26
US Application 60/192,712
Filed on 2000-03-28
US Pat 7,659,085

Issued 2010-02-09

Updated

Feb 6, 2014

Data Source: 
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