Technology Bundle ID: TAB-2763

Methods of Retaining Methylation Pattern Information in Globally Amplified DNA

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Primary Inventors: 
Mangalathu Rajeevan (CDC)
Elizabeth Unger (CDC)
Development Stage: 
Pre-Clinical (in vitro)
Development Status: 

In vitro data available

Institute or Center: 

CDC researchers have developed a novel method that generates globally amplified DNA copies retaining parental methylation information; making accurate DNA-archiving for methylation studies much more feasible and cost-effective than undertaking such an endeavor with alternate technologies. This unique approach eliminates a significant bottleneck in the collection of methylation information in the genome(s) of an individual organism, hosts and pathogens. Thus, this technology provides numerous opportunities for investigations into cytosine methylation patterns, ultimately benefiting efforts of early detection, control and prevention of many chronic and infectious diseases.

  • Epigenetics investigators and related products manufacturers
  • Studies into pathogenesis regulation, chronic diseases, gene silencing, etc.
  • Cancer and obesity research
  • Basic research applications
  • Overcomes a significant barrier inhibiting efficient DNA methylation archival studies
  • Substantially reduces the required quantity of sample DNA
  • Developed kits will be universally applicable to all species using DNA methylation as regulatory mechanisms of growth, development and/or pathogenesis
  • Usable in all situations of limited amounts of DNA, including studies with single cells
  • Improved cost effectiveness and study feasibility compared to alternate technologies


US Application 60/785,000
Filed on 2006-03-22
US Pat 7,820,385

Issued 2010-10-26


Rajeevan MS, et al.
PMID 17045346


Feb 6, 2014

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