Technology Bundle ID: TAB-2747

Recombinant Nucleic-Acid Based Flavivirus Nucleic Acids for Development of Vaccines and/or Sero-diagnostics

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Primary Inventors: 
Gwong-Jen Chang (CDC)
Development Stage: 
Pre-clinical (in vivo)
Development Status: 
  • In vitro data available
  • In vivo data available (animal)
Institute or Center: 

CDC scientists have developed recombinant flavivirus nucleic acids for the generation of broad protective immunity against flaviviruses, as well as the development of sensitive serologic diagnostic tools. Mosquito borne viral encephalitis is often caused by a flavivirus, such as Japanese encephalitis virus, dengue virus or West Nile virus. Infection by these pathogens is often lethal to both humans and animals.

Specifically, these novel recombinant nucleic acids encode critical structural proteins of flaviviruses, such as yellow fever virus. The invention provides for a method of immunizing a subject against infection by a number of pathogenic flaviviruses. Furthermore, generated antigenic subviral particles can also serve as a tool for the development of specific, antibody detection-based flavivirus diagnostic assays.

  • Development of a broadly useful commercial vaccine for pathogenic flaviviruses
  • Insect-borne disease monitoring and surveillance programs
  • Generated antigen can be used for high-specificity serologic diagnostic assays
  • In vivo animal studies demonstrate specific antibody generation and complete protection
  • Desired immune response provided by a single intramuscular injection in both murine and equine studies
  • Potential for vaccine use and the development of commercial flavivirus infection diagnostic assays and kits


PCT Application PCT/US1999/012298
Filed on 1999-06-03
US Application 11/182,029
Filed on 2005-07-13
US Application 60/087,908
Filed on 1998-06-04
US Pat 7,417,136

Issued 2008-08-26
US Pat 8,105,609

Issued 2012-01-31
US Pat 8,728,488

Issued 2014-05-20

Various international patent applications pending or issued


Chang GJ, et al.
PMID 10756038
Chang GJ, et al.
PMID 11797784


Jan 28, 2014

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