Technology Bundle ID: TAB-2743

Molecular Detection and Viral-Load Quantification for HIV-1 Groups M, N and O, and Simian Immunodeficiency Virus-cpz (SIVcpz)

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Licensing Contact:
Primary Inventors: 
Renu Lal (CDC)
Co-Inventors: 
Danuta Pieniazek (CDC)
Development Stage: 
Pre-Clinical (in vitro)
Development Status: 
  • In vitro data available
  • In situ data available (on-site)
Institute or Center: 
CDC

This invention provides materials, methods, and assays for detecting HIV-1 groups M and O and optionally HIV-1 group N and simian immunodeficiency virus-cpz (SIV-cpz). Specific nucleic acid primers for hybridization, amplification, and detection of HIV-1 are also provided for. The nucleic acid amplification assays can detect small concentrations of HIV-1 and are also useful for quantitative examinations of viral load concentrations within biological samples.

Applications:
  • Blood and plasma donation screening
  • Diagnostic detection of HIV-1
  • Public health programs
  • Monitoring HIV treatment and disease inhibition/progression
Advantages:
  • Broad-use, generic viral detection for groups M, N and O HIV-1, and also SIVcpz
  • Requires minute quantities of virus for use, making this assay ideal for confirmation of early-stage infection
  • Sensitive and highly specific
  • Easily formulated for kits
  • Established efficacy in patient samples

Patents

PCT Application PCT/US2000/002498
Filed on 2000-02-01
US Application 09/890,551
Filed on 2001-08-01
US Application 10/980,660
Filed on 2004-08-01
US Application 60/118,357
Filed on 1999-02-03
US Pat 8,575,324

Issued 2013-11-05

Publications

Yang C, et al.
PMID 10823786

Updated

Jan 28, 2014

Data Source: 
tts