Technology Bundle ID: TAB-2730

Antigen, Encoding Gene, Related Monoclonal Antibody and Hybridoma Clones for Streptococcus pneumoniae Serological Diagnostics

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Licensing Contact:
Primary Inventors: 
Harold Russell (CDC)
Co-Inventors: 
Jacquelyn Sampson (CDC), Steven O'connor (CDC)
Development Stage: 
Pre-Clinical (in vitro)
Development Status: 

In vitro data available

Institute or Center: 
CDC

This CDC developed invention pertains to Streptococcus pneumoniae protein "pneumococcal fimbrial protein A (PfpA)," as well as the encoding pfpA gene. S. pneumoniae linked pneumococcal disease is prevalent among the very young, the elderly and also immunocompromised individuals. This invention covers the breadth of directly PfpA-related technology that might be employed for development of diagnostic tests for S. pneumoniae and/or vaccines directed against the pathogen. In addition to the the intellectual property protected amino acid sequence and encoding plasmid, monoclonal antibodies and corresponding hybridomas are also available.

Applications:
  • Screening diagnostic young, elderly and immunocompromised patients for possible S. pneumoniae infection
  • Pneumococcal disease vaccine development or refinement
Advantages:
  • Easily adapted to a high-throughput assay for mass screening purposes
  • Can be formatted as an on-site, lateral-flow diagnostic; both PfpA antigen and anti-PfpA mAb are available

Patents

US Pat 5,422,427

Issued 1995-06-06
US Pat 6,312,944

Issued 2001-11-06

Publications

Russell H, et al.
PMID 2229341
Sampson JS, et al.
PMID 7505262

Updated

Jan 20, 2014

Data Source: 
tts