Technology Bundle ID: TAB-2727

Rapid Detection of Antiretroviral(s) Drug-Resistant HIV-1 within Clinical Samples

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Primary Inventors: 
Walid Heneine (CDC)
Co-Inventors: 
Gerardo Lerma (CDC), Shinji Yamamoto (CDC), Thomas Folks (CDC), William Switzer (CDC)
Development Stage: 
Pre-Clinical (in vitro)
Development Status: 

In vitro data available

Institute or Center: 
CDC

One of the problems with the development of current therapies for HIV infection is that the virus rapidly develops resistance to drugs such as reverse transcriptase (RT) inhibitors. CDC researchers have developed an enzyme-based methodology for detecting phenotypic resistance to antiretroviral drugs whose mode of action decreases the efficiency of the HIV-1 RT enzyme.

This invention will enhance clinical monitoring by providing data that tells physicians if and when the HIV-1 infecting a patient has become resistant to commonly used antiretroviral drugs, such as zidovudine/azidothymidine (AZT), nevirapine and lamivudine (3TC). This invention provides physicians and patient care facilities with a simple, rapid lab test that will tell them when a particular antiviral drug is not or no longer beneficial for a patient. Additionally this technology is superior to current culture-based methods for determining phenotypic resistance to HIV antiviral drugs, which are time-consuming and labor-intensive and therefore impractical for clinical monitoring.

Applications:
  • Clinical monitoring of individual patient antiretroviral therapy
  • HIV/AIDS public health programs
  • Surveillance of retroviral drug resistance
Advantages:
  • Rapid diagnostic which greatly reduces time and labor for improved clinical monitoring of HIV treatment
  • Ready for commercialization
  • Easily adapted to kit format
  • Assists continued usefulness of common antiretroviral therapeutics

Patents

PCT Application PCT/US1999/013957
Filed on 1999-06-18
US Application 10/190,101
Filed on 2002-07-03
US Application 60/090,051
Filed on 1998-06-19
US Pat 6,787,126

Issued 2004-09-07
US Pat 7,691,572

Issued 2010-04-06

Various international patents issued

Various international patents issued or pending

Publications

Qari SH, et al.
PMID 12212925

Updated

Jan 20, 2014

Data Source: 
tts