Technology Bundle ID: TAB-2721

Respiratory Syncytial Virus Immunogens for Vaccine and Therapeutics Development

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Primary Inventors: 
Lia Haynes (CDC), Ralph Tripp (CDC)
Co-Inventors: 
Larry Anderson (CDC)
Development Stage: 
Pre-clinical (in vivo)
Development Status: 
  • In vitro data available
  • In vivo data available (animal)
  • Institute or Center: 
    CDC

    CDC researchers have developed specific Respiratory Syncytial Virus (RSV) immunogens for use in the development of RSV-directed vaccines and therapeutics. RSV is the most common cause of serious respiratory disease in infants and young children and an important cause of disease in the elderly. To date, efforts to make a mutually safe and effective vaccine have been largely unsuccessful. This invention addresses both problems.

    CDC and collaborative researchers have demonstrated that a vaccine based on amino acid sequences corresponding to group-specific regions of the RSV G-protein can effectively induce antibodies, facilitate virus clearance, decrease the virus-induced inflammatory response to RSV challenge, and also decrease the enhanced disease following RSV challenge. This composition may be used alone as a vaccine to safely protect infants, children, and adults from RSV, as a booster with other RSV proteins or with inactivated virus as a vaccine to ensure that it can be given safely and effectively improve protection from RSV.

    Applications:
    • Prophylactic and therapeutic for the prevention and treatment of RSV infections
    • Single or multi-component vaccine against RSV
    • Improvements to currently developed/developing vaccines
    • Developed antibodies may be employed for use in passive immunity or RSV research
    Advantages:
    • Increased safety, effectiveness compared to current vaccines
    • Findings suggest likely prevention or mitigation of RSV-related pulmonary disease for previously established infections

    Patents

    PCT Application PCT/US2010/044434
    Filed on 2010-08-04
    US Application 61/231,162
    Filed on 2009-08-04
    US Pat 8,771,706

    Issued 2014-07-08
    US Pat 8,846,056

    Issued 2014-09-30

    Several international patent applications pending

    Publications

    Haynes LM, et al.
    PMID 19545210
    Miao C, et al.
    PMID 19264600

    Updated

    Jan 16, 2014

    Data Source: 
    tts