Technology Bundle ID: TAB-2712

Detection and Differentiation of Pathogenic Fungi in Clinical Samples Using a Multi-Analyte Profiling System

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Licensing Contact:
Primary Inventors: 
Christine Morrison (CDC)
Co-Inventors: 
Brian Holloway (CDC), Sanchita Das (CDC), Teresa Brown (CDC)
Development Stage: 
Pre-Clinical (in vitro)
Development Status: 
  • Early-stage
  • In vitro data available
Institute or Center: 
CDC

This invention provides a rapid, sensitive and specific diagnostic tool for the detection of pathogenic fungi and subsequent species-specific discrimination. CDC scientists have developed nucleic acid probes to identify the six most medically important Candida species and endemic mycoses, and to differentiate them from other medically important fungi in a multi-analyte profiling system. Candida fungi are one of the leading causes of clinically-acquired bloodstream infections and, although improved antifungal compounds have been recently introduced, they have unique, species-specific treatment responses.

This multi-analyte approach has the potential to simultaneously identify up to 100 different fungi in one assay. Additionally, the assay is quite cost effective in terms of resource input, time invested and technician labor. Used in conjunction with contemporary antifungal medications, this assay provides a very rapid and specific diagnosis allowing for the selective administration of appropriate compounds and ultimately improved patient outcomes.

Applications:
  • Directing antifungal drug therapy for improved patient outcomes
  • Detection, discrimination of Candida species from biological samples
  • High-throughput screening
  • Liquid or solid phase microarray development to detect medically important fungi
Advantages:
  • Rapid, sensitive, simple and specific
  • Multi-analyte nature provides cost-efficiency
  • Easily adaptable to kit form
  • Permits the multiplexing of up to 100 different hybridization reactions in a single sample

Patents

PCT Application PCT/US2006/037640
Filed on 2006-09-26
US Application 60/721,419
Filed on 2005-09-27
US Pat 8,119,788

Issued 2012-02-21

Several international filings issued or pending.

Publications

Das, S. et al.
PMID 16487306

Updated

Jan 8, 2014

Data Source: 
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