Technology Bundle ID: TAB-2711

Personal Air Sampler for Collecting Airborne Aerosol Particulates for Molecular Analysis by Size

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Licensing Contact:
Primary Inventors: 
Teh-Hsun Chen (CDC)
Co-Inventors: 
Herbert Edgell (CDC), Jyoti Keswani (CDC)
Development Stage: 
Prototype
Development Status: 
  • In situ data available (on-site)
  • Prototype
Institute or Center: 
CDC

This invention consists of a sampling apparatus that utilizes one or more cyclone separators to collect airborne particles from the atmosphere. The apparatus not only separates out aerosols from the atmosphere, but also serves as a collection tube for aerosol particles. Through its unique design, this CDC-developed apparatus is able to use the centrifugal force of the air flow on aerosolized particles forcing them to separate by size. Since the sample is collected directly in a microcentrifuge tube, in situ analysis of the ambient particulates can be performed. Analysis may include, but is not limited to, PCR, immunoassay analysis, microscopic spore counting, and counting colony-forming units. The device should also have many additional uses for environmental surveillance and occupational health applications.

Applications:
  • Analysis of ambient air particulates
  • Environmental surveillance
  • Occupational safety monitoring
  • Biodefense
  • Long-term exposure assessment
Advantages:
  • Rapid, on-site sampling and analysis.
  • Alternative to surface-sampling and culturing for aerosolized biological agents.
  • Superior extraction efficiency compared to filters, impingers, and impactors.
  • Real-world testing demonstrated device's ability to collect airborne mold and mycotoxins, pollen and pollen fragments, airborne dust particulates, as well as airborne influenza virus in a hospital environment.

Patents

PCT Application PCT/US2004/032378
Filed on 2004-10-01
US Application 60/512,252
Filed on 2003-10-17
US Pat 7,370,543

Issued 2008-05-13
US Pat 8,205,511

Issued 2012-06-26

Publications

Blachere FM, et al.
PMID 19453416
CDC-NIOSH Cyclone Bioaerosol Sampler webpage
http://www.cdc.gov/niosh/topics/aerosols/biosampler.html
Cao G, et al.
PMID 21975583
Lindsley WG, et al.
PMID 17075620
Lindsley WG, et al.
PMID 21152051
Macher JM, et al.
PMID 18720289
Macher JM, et al.
PMID 18780236
NIOSH Personal Bioaerosol Cyclone Sampler video
YouTube
Su WC, et al.
PMID 22833144
Wang CH, et al.
PMID 25799419

Updated

Jan 8, 2014

Data Source: 
tts