Technology Bundle ID: TAB-2701

Nucleic Acid-based Compositions and Methods for the Detection of Pathogenic Candida or Aspergillus Fungi Species

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Licensing Contact:
Primary Inventors: 
Christine Morrison (CDC)
Co-Inventors: 
Brian Holloway (CDC), Errol Reiss (CDC), Jong Shin (CDC)
Development Stage: 
Pre-Clinical (in vitro)
Development Status: 

In vitro data available

Institute or Center: 
CDC

This invention pertains to the development of oligonucleotides for the rapid nucleic acid-based identification of Candida or Aspergillus fungi species in biological samples. This identification is accomplished by the targeting the internally transcribed spacer-2 (ITS2) region that are unique to various Candida species. The assay is sensitive, specific and rapid. Implementation of the technology will facilitate earlier specific diagnoses, and lead to better antifungal therapy implementation for infected patients.

Applications:
  • Directing antifungal drug therapy for improved patient outcomes
  • Detection, discrimination of Candida and Aspergillus species from biological samples
  • Addressing secondary infections of immunosuppressed individuals
Advantages:
  • Easily adapted for use in kits
  • High-throughput capable
  • Rapid and cost-effective

Patents

PCT Application PCT/US1997/016423
Filed on 1997-09-15
US Application 60/026,387
Filed on 1996-09-16
US Pat 6,235,890

Issued 2001-05-22

Publications

Shin JH, et al.
PMID 9854084

Updated

Dec 23, 2013

Data Source: 
tts