Technology Bundle ID: TAB-2697

Species-specific Nucleic Acid Detection Assay for Fungi

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Licensing Contact:
Primary Inventors: 
Christine Morrison (CDC)
Co-Inventors: 
Errol Reiss (CDC), Jong Soo Choi (CDC), Lilianna Aidorevich (CDC)
Development Stage: 
Pre-Clinical (in vitro)
Development Status: 

In vitro data available

Institute or Center: 
CDC

This invention pertains to nucleic acid-based assays for the detection of Aspergillus and other filamentous fungi. Assays cover the species-specific detection and diagnosis of infection by Aspergillus, Fusarium, Mucor, Penecillium, Rhizomucor, Absidia, Cunninghamella, Pseudallescheria or Sporthrix in a subject. This can reduce identification time from several days by conventional culture methods to a matter of hours. Furthermore, genus-specific probes are also provided for Aspergillus, Fusarium and Mucor, in addition to an "all-fungus" nucleic acid probe. This technology is readily adaptable as kits used for species-specific identification of opportunistic pathogen infections or possible work/home contamination.

Applications:
  • Directing antifungal drug therapy for improved patient outcomes
  • Detection, discrimination of fungal species from biological samples
  • Addressing secondary infections of immunosuppressed individuals or asthmatics
Advantages:
  • Rapid, sensitive, simple and specific
  • Cost-efficiency compared to culture or sero-diagnostic methods
  • Easily adaptable to kit form
  • High-throughput screening

Patents

PCT Application PCT/US1998/008926
Filed on 1998-05-01
US Application 60/045,400
Filed on 1997-05-01
US Pat 6,372,430

Issued 2002-04-16
US Pat 7,052,836

Issued 2006-05-30

Updated

Dec 23, 2013

Data Source: 
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