Technology Bundle ID: TAB-2695

Human Rotavirus Strains and Vaccines for Neonatal Childhood Protection

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Licensing Contact:
Primary Inventors: 
Baoming Jiang (CDC)
Co-Inventors: 
Jon Gentsch (CDC), Roger Glass (CDC), Yuhuan Wang (CDC)
Development Stage: 
Pre-clinical (in vivo)
Development Status: 
  • In vitro data available
  • In vivo data available (animal)
Institute or Center: 
CDC

This invention relates to rotavirus vaccine compositions and methods of vaccination. Rotaviral infection is the most commonly occurring gastrointestinal illness of children world, affecting both developed and developing economies. Additionally, rotavirus infections can affect livestock (especially calves and piglets), and resulting mortality/morbidity cause major economic losses for farmers and nations each year.

The vaccine strains include Rotavirus A CDC-9 (P[4]Gl) and CDC-66 (P[4]G2 serotype). These strains represent common rotavirus serotypes and may serve as improvements or alternatives to current live, oral rotavirus vaccine strains. Further, this technology has demonstrated efficacy in a large animal (piglets) modeling.

Applications:
  • Novel rotavirus vaccines
  • Neonatal/childhood vaccination initiatives
  • Rotavirus surveillance programs, important for both developing and developed nations
Advantages:
  • Isolated strains are representative of those involved in community-acquired infection
  • Suitable for the development of improved, broadly effective rotavirus vaccines
  • Can be developed for injection and/or oral vaccine administration
  • Derived vaccines may be administered alone or in combination with other vaccines

Patents

PCT Application PCT/US2010/034537
Filed on 2010-05-12
US Application 16/672,168
Filed on 2019-11-01
US Application 61/177,393
Filed on 2009-05-12
US Pat 10,500,269

Issued 2019-12-10
US Pat 8,822,192

Issued 2014-09-02
US Pat 9,498,526

Issued 2016-11-22
US Pat 9,974,851

Issued 2018-05-22

Various international filings pending or deferred

Publications

Esona MD, et al.
[PMID 20009519]
Jiang B, et al.
[PMID 23744507]
Wang Y, et al.
[PMID 20558244]

Updated

Dec 23, 2013

Data Source: 
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