Technology Bundle ID: TAB-2672

Human Influenza Virus Real-time RT-PCR Detection and Characterization Panel

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Primary Inventors: 
Stephen Lindstrom (CDC)
Co-Inventors: 
Alexander Klimov (CDC), Lamorris Loftin (CDC), Nancy Cox (CDC)
Development Stage: 
Pre-Clinical (in vitro)
Development Status: 

In vitro data available

Institute or Center: 
CDC

This invention relates to methods of rapidly detecting influenza, including differentiating between type and subtype. Unlike culture and serological tests requiring 5 to 14 days for completion, CDC researchers developed a rapid, accurate assay, which is easily adapted to kit form. This assay also requires less labor input than immunoassays. These methods can be used to quickly identify a broad variety of influenza types and subtypes, including viruses that may be involved in pandemics (such as H5N1, for example).

Applications:
  • Influenza diagnostic using clinical specimens
  • High-throughput screenings
  • Influenza surveillance programs
Advantages:
  • Already FDA approved
  • Especially useful for H5N1 screening
  • Sensitive detection
  • Specific discrimination of influenza subtypes
  • Easily formatted as kit or array
  • Faster than culturing and serological identification methods
  • Less laborious and more objective than immunoassays

Patents

PCT Application PCT/US2007/003646
Filed on 2007-02-12
US Application 60/772,806
Filed on 2006-02-13
US Pat 10,036,076

Issued 2018-07-31
US Pat 10,196,699

Issued 2019-02-05
US Pat 8,241,853

Issued 2012-08-14
US Pat 8,568,981

Issued 2013-10-29
US Pat 9,382,592

Issued 2016-07-05

Various international filings pending

Publications

Jernigan DB, et al.
PMID 21342897

Updated

Nov 19, 2013

Data Source: 
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