Technology Bundle ID
TAB-2648

Real-time PCR Multiplex Assay for Detection of Bacterial Respiratory Pathogens in Clinical Specimens

Applications
Diagnostics
Linked ID
E-300-2013-0
Lead Inventors
Jonas Winchell (CDC)
Co-Inventors
Agnes Warner (CDC)
Kathleen Thurman (CDC)
Development Status
  • Pre-clinical
  • In vitro data available
Therapeutic Areas
Infectious Disease
ICs
CDC
CDC researchers have developed a single-tube, real-time PCR assay for the simultaneous detection of three bacterial respiratory pathogens (Mycoplasma pneumoniae, Chlamydiophila pneumoniae and Legionella spp.). The assay has an internal control testing for presence of human DNA. This four-plex real-time PCR assay could potentially become a routine screening test for patients with respiratory illness. Ninety four clinical specimens (in a 96-well format) can be tested at once. This assay is non-invasive, rapid and cost-effective. It has the potential for point-of-care applications in population-based pneumonia surveillance.
Commercial Applications
  • Population-based pneumonia surveillance
  • Development of broadly-capable respiratory clinical diagnostics
Competitive Advantages
  • Sensitive and specific
  • High-throughput friendly
  • Rapid and cost-effective compared to screening for individual respiratory pathogens
  • Easily developed for use in diagnostic kits

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