Technology Bundle ID: TAB-2645

Multiplex Real-time PCR Assay for Detection of Numerous Bacterial Pathogens

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Licensing Contact:
Primary Inventors: 
Jonas Winchell (CDC)
Co-Inventors: 
Bernard Wolff (CDC), Maureen Diaz (CDC)
Therapeutic Area: 
Infectious Disease
Application: 
Diagnostics
Development Status: 
  • Pre-clinical
  • In vitro data available
Institute or Center: 
CDC

In order to address a global need for rapid, cost-effective, sensitive, and specific assays for many pathogens, CDC scientists have developed a broad-use, multiplexed RT-PCR assay. This comprehensive assay covers numerous pathogens that are common causes of infection in neonates and also important to food-safety. Specifically, this assay (and respective probes, primers, and kits) is capable of detecting one or more of Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Toxoplasma gondii, Moraxella catarrhalis, Escherichia coli, Shigella, Staphylococcus aureus, Pneumocystis jirovecii, Chlamydia trachomatis, Ureaplasma urealyticum, Ureaplasma parvum, Ureaplasma spp., Bartonella spp., Streptococcus agalactiae, and Neisseria meningitidis in a biological sample.

Applications:
  • Clinical diagnostic for several pathogens
  • Drug-resistance surveillance
  • Public health monitoring
  • En masse food-safety screening
Advantages:
  • Cost-effective
  • Simple to implement
  • Rapid, accurate and objectively conclusive
  • Easily implemented into kit format
  • Ideal for high-throughput scenarios

Patents

PCT Application PCT/US2013/028034
Filed on 2013-02-27
US Application 16/056,147
Filed on 2018-08-06
US Application 61/642,091
Filed on 2012-05-03
US Pat 10,072,305

Issued 2018-09-11

Publications

Diaz MH, et al.
PMID 23805203

Updated

Sep 18, 2013

Data Source: 
tts