Aortic Access from Vena Cava for Large Caliber Transcatheter Cardiovascular Interventions

The invention pertains to a device and method for transcatheter correction of cardiovascular abnormalities, such as the delivery of prosthetic valves to the heart. Featured is a device implant for closing a caval-aortic iatrogenic fistula created by the introduction of a transcatheter device from the inferior vena cava into the abdominal aorta. The occlusion device includes an expandable transvascular implant with an elastomeric surface capable of extending between a vein and artery which conforms to the boundaries of an arteriovenous fistula tract between the artery and vein. A guidewire channel is disposed within the occlusion device where the channel also has elastomeric wall surfaces that conform or can be expanded to the area so that it occludes the channel when the guidewire is not present. The implant is resiliently deformable into a radially compressed configuration for delivery through the catheter. When not deformed into the radially compressed configuration, the distal end of the device is radially enlarged, relative to the intermediate neck, whereby the distal end forms an enlarged distal skirt, such as a disk or button shaped member. A polymer coating on the radially enlarged distal end conforms to the endoluminal aortic wall for deployment against an internal wall of the artery.

Potential Commercial Applications: Competitive Advantages:
  • Cardiovascular surgery
  • Heart valve implantation
  • Valve-repair
  • Closure of the caval-aortic iatrogenic fistula
  • Vascular access

Robert Lederman (NHLBI)
Ozgur Kocaturk (NHLBI)

Intellectual Property:
US Application No. 61/863,071

Kodali SK, et al. PMID 22443479
Makkar RR, et al. PMID 22443478
Smith CR, et al. PMID 21639811

Licensing Contact:
Michael Shmilovich , Esq.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325
Rockville , MD 20852
Phone: 301-435-5019
Fax: 301-402-0220

OTT Reference No: E-553-2013/0

Updated: 09/10/2013