Salen-Manganese Compounds for Therapy of Viral Infections


Salen-manganese compounds are synthetic, stable, low toxicity, low cost agents that may provide protection from immune reaction-related oxidative cell damage associated with many illnesses. In particular, oxidative cell damage has been associated with many viral infections including influenza. This invention demonstrates that treating mice with salen-manganese compounds, after lethal pandemic influenza virus infection, significantly enhances survival. Salen-manganese treatment also reduces lung pathology and also improved cellular recovery and repair. Because oxidative damage is observed in many viral infections, administration of salen-manganese compounds may have therapeutic relevance to a wide range of viral infections, in addition influenza. Existing viral therapeutics merely target the infectious viral agent and not the damage caused by the immune system reaction related to infection. Because, salen-manganese treatments target the untapped therapeutic space of infection-induced, immune system-related pathology and have favorable safety and cost profiles, such therapies are ideal candidates for development.

Potential Commercial Applications: Competitive Advantages:
Viral therapeutics.   Synthetic, stable, low toxicity, low cost, untapped therapeutic target space.


Inventors:
John Kash (NIAID)
Jeffrey Taubenberger (NIAID)
Rodney Levine (NHLBI)
Susan Doctrow


Intellectual Property:
PCT Application No. PCT/US2012/064383
US Application No. 61/558,137

Publications:
Doctrow SR, et al. Salen Manganese Complexes: Multifunctional Catalytic Antioxidants Protective in Models for Neurodegenerative Diseases of Aging. In: Medicinal Inorganic Chemistry, ACS Symposium Series, Vol. 903, Chapter 18, pp 319-347; August 25, 2005. DOI: 10.1021/bk-2005-0903.ch018
Schwarz KB. PMID 8891667

Collaboration Opportunity:

The NIAID Laboratory of Infectious Diseases, Viral Pathogenesis and Evolution Section, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize this technology. For collaboration opportunities, please contact Maryann Puglielli at 301-594-6656.


Licensing Contact:
Edward (Tedd) Fenn ,
NIH Office of Technology Transfer
Email: fennea@mail.nih.gov
Phone: 301-435-5031

OTT Reference No: E-281-2011/0

Updated: Jul-20-2012