Diagnostic Assays and Methods of Use for Detection of Filarial Infection


The effort targeting the mosquito borne neglected tropical disease lymphatic filariasis for elimination through mass drug administration by 2020 will require accurate, cost effective methods for detecting early infections. The World Health Organization-recommended immunochromatographic test detects adult Wuchereria bancrofti (Wb) antigen in blood, but shows variable efficacy due to the complex life cycle of the parasites and cross reactivity with other organisms. This variability may hinder effective lymphatic filariasis elimination efforts. This new technology improves available detection methods through use of an isolated immunoreactive antigen, Wb123, from infective stage larvae (L3) Wb; which results in specific detection early in the infective cycle with reduced cross reactivity. This technology may see wide application in testing and surveillance of lymphatic filariasis as part of the effort to eliminate the disease worldwide.

Potential Commercial Applications: Competitive Advantages:
  • Diagnostics testing
  • Infectious disease monitoring
  Improved detection of early stage lymphatic filariasis


Inventors:
Thomas Nutman (NIAID)
Doran Fink (NIAID)
Joseph Kubofcik (NIAID)
Peter Burbelo (NIDCR)


Intellectual Property:
PCT Application No. PCT/US2011/58561
US Application No. 61/410,239
US Application No. 13/882,850


Publications:
Senbagavalli P, et al. PMID 21734131
Bennuru S, et al. PMID 21606368
Steel C, et al. PMID 21559422
Fink DL, et al. PMID 20980560
Bennuru S, et al. PMID 20889885

Licensing Contact:
Edward (Tedd) Fenn ,
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325
Rockville , MD 20852
Email: fennea@mail.nih.gov
Phone: 301-435-5031
Fax: 301-402-0220

OTT Reference No: E-281-2010/0

Updated: 09/29/2011