Diagnostic Assays and Methods of Use for Detection of Filarial Infection


The effort targeting the mosquito borne neglected tropical disease lymphatic filariasis for elimination through mass drug administration by 2020 will require accurate, cost effective methods for detecting early infections. The World Health Organization-recommended immunochromatographic test detects adult Wuchereria bancrofti (Wb) antigen in blood, but shows variable efficacy due to the complex life cycle of the parasites and cross reactivity with other organisms. This variability may hinder effective lymphatic filariasis elimination efforts. This new technology improves available detection methods through use of an isolated immunoreactive antigen, Wb123, from infective stage larvae (L3) Wb; which results in specific detection early in the infective cycle with reduced cross reactivity. This technology may see wide application in testing and surveillance of lymphatic filariasis as part of the effort to eliminate the disease worldwide.

Potential Commercial Applications: Competitive Advantages:
  • Diagnostics testing
  • Infectious disease monitoring
  Improved detection of early stage lymphatic filariasis


Related Inventoion(s):
E-084-2010/0
E-014-2011/0


Inventors:
Thomas Nutman (NIAID)
Doran Fink (NIAID)
Joseph Kubofcik (NIAID)
Peter Burbelo (NIDCR)


Intellectual Property:
PCT Application No. PCT/US2011/58561
US Application No. 61/410,239
US Application No. 13/882,850

Publications:
Senbagavalli P, et al. PMID 21734131
Bennuru S, et al. PMID 21606368
Steel C, et al. PMID 21559422
Fink DL, et al. PMID 20980560
Bennuru S, et al. PMID 20889885

Collaboration Opportunity:

The National Institute of Allergy and Infectious Disease (NIAID) is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize Diagnostic Assays and Methods of Use for Detection of Filarial Infection. For collaboration opportunities, please contact Johanna Schneider, Ph.D. at Schneiderjs@niaid.nih.gov or 301-451-9824.


Licensing Contact:
Edward (Tedd) Fenn ,
NIH Office of Technology Transfer
Email: fennea@mail.nih.gov
Phone: 301-435-5031

OTT Reference No: E-281-2010/0

Updated: Sep-29-2011