Multi-Antigenic Peptide(s) Vaccine and Immunogen for Conferring Streptococcus pneumoniae Immunity
Disease caused by Streptococcus pneumoniae (pneumococcus) is an important cause of morbidity and mortality in the United States and developing countries. Pneumococcal disease is prevalent among the very young, the elderly and immunocompromised individuals. This invention is an improved, immunogenic peptide construct consisting of a combination of antigenic epitopes of the PsaA (37-kDa) protein from S. pneumoniae. In addition, the peptides of the invention have the capability of serving as specific immunogens in a subject, effectively eliciting the production of antibodies and conferring protective immunity against S. pneumoniae infection following immunognen administration.
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George Carlone (CDC)
Edwin Ades (CDC)
Jacquelyn Sampson (CDC)
Scott Johnson (CDC)
Danny Jue (CDC)
US Application No. 09/613,092
PCT Application No. PCT/US2001/021626
US Application No. 11/145,814
US Application No. 12/360,382
Various international patent applications pending or issued
Tara Kirby , Ph.D.
NIH Office of Technology Transfer
OTT Reference No: E-248-2013/1