Norovirus-neutralizing Monoclonal Antibodies


Vaccines and therapies to prevent and treat Norovirus infections do not exist, despite the worldwide prevalence of Norovirus infections. Outbreaks of human gastroenteritis attributable to Norovirus commonly occur in group setting, such as hospitals, nursing homes, schools, dormitories, cruise ships and military barracks.

This technology relates to monoclonal antibodies, which specifically bind to Norovirus and have therapeutic potential. In a primate model, these antibodies stimulated a strong adaptive immune response which may produce a protective effect. These Norovirus antibodies may have application as immunoprophylaxis to protect individuals from infections or as a possible treatment for infected individuals.

Potential Commercial Applications: Competitive Advantages:
  • Therapeutic
  • Vaccine
 
  • Currently, no vaccines or therapies exist to prevent and treat Norovirus infections.


Inventors:
Zhaochun Chen (NIAID)
Robert Purcell (NIAID)
Lisbeth Kim Green (NIAID)
Stanislav Sosnovtsev (NIAID)
Karin Bok (NIAID)


Intellectual Property:
US Application No. 61/763,879


Licensing Contact:
Edward (Tedd) Fenn ,
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325
Rockville , MD 20852
Email: fennea@mail.nih.gov
Phone: 301-435-5031
Fax: 301-402-0220

OTT Reference No: E-226-2011/0

Updated: 09/10/2013