Real-time RT-PCR Assay for the Detection of Rift Valley Fever Virus in Humans and Livestock


A quantitative RT-PCR-based assay has been developed to rapidly detect all known strains of Rift Valley fever virus (RVFV). RVFV infections occur in both humans and livestock animals resulting in significant mortality and economic loss. Upon outbreak, RVFV has been known to cause devastating loss among livestock (primarily sheep and cattle) with outbreaks characterized by sweeping "abortion storms" and elevation newborn animal mortality approaching 100% in affected areas. The CDC-developed assay is capable of detecting and quantifying RVFV infection in both human and veterinary samples.

Potential Commercial Applications: Competitive Advantages:
  • Diagnostic assay for the detection of Rift Valley fever virus in human and veterinary samples
  • Research tool to quantitatively measure viral load in laboratory specimens
 
  • Assay detects positive infections for 33 known variants of Rift Valley fever virus.
  • Easily adaptable to kits for high-throughput screening of a large number of samples at once, useful for ensuring herd-health for example.


Related Invention(s):



Inventors:
Brian Bird (CDC)
Stuart Nichol (CDC)


Intellectual Property:
US Application No. 60/869,324
Research Tool – Patent protection is not being pursued for this technology.

Publications:
Bird BH, et al. PMID 17192303
Bird BH, et al. PMID 18786992

Licensing Contact:
Tara Kirby , Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325
Rockville , MD 20852
Email: kirbyt@mail.nih.gov
Phone: 301-435-4426
Fax: 301-402-0220

OTT Reference No: E-187-2013/0

Updated: 01/16/2014