Use of Erythropoietin and Derivatives for Treatment of Hypertension


Erythropoietin (EPO), a natural hormone produced by kidneys, is associated with stimulation of red blood cell production. Recombinant human erythropoietin (rhEPO) is currently used for treatment of anemia and has powerful cardioprotective properties. Hypertension remains a major health problem and a serious risk factor for stroke and chronic heart failure. Researchers at the NIH have discovered that administering a therapeutically effective dose of rhEPO or an EPO derivative, including carbamylated erythropoietin (CEPO) and Helix B surface peptide (HBSP), acutely reduces both systolic and diastolic blood pressure via Nitric Oxide (NO) signaling. Long-term administration of HBSP prevents elevation of arterial blood pressure in an animal model of hypertension. Unlike long-term treatment with rhEPO, administration of EPO derivatives, such as HBSP, does not stimulate excessive red cell production and will be useful in the development of anti-hypertensive drugs.

Potential Commercial Applications: Competitive Advantages:
Therapeutics for treatment of hypertension.  
  • Administration of EPO and its derivatives do not stimulate excessive red blood cell production.
  • This technology utilizes activation of natural vasodilation mechanisms.
  • rhEPO and EPO derivatives provide tissue-protective properties which none of the existing antihypertensive drugs provide.


Inventors:
Mark Talan (NIA)
Ismayil Ahmet (NIA)
Edward Lakatta (NIA)


Intellectual Property:
US Application No. 61/636,547
US Application No. 61/638,328
US Application No. 61/656,698

Collaboration Opportunity:

The National Institute on Aging is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize a new anti-hypertensive drug based of non-erythropoietic derivatives of erythropoietin that combines vasodilative and tissue protective properties. For collaboration opportunities, please contact Vio Conley, M.S. at conleyv@mail.nih.gov. Click here to view the NIA collaborative opportunity announcement.


Licensing Contact:
Vince Contreras , Ph.D.
NIH Office of Technology Transfer
Email: vincent.contreras@nih.gov
Phone: 301-435-4711

OTT Reference No: E-158-2012/0

Updated: Sep-11-2012