Nitric Oxide-Releasing Polyvinylpyrrolidone-Based Polymers for Wound Healing and Related Applications

Novel nitric oxide-releasing polyvinylpyrrolidone-based polymers, their compositions, and use in treating wounds. The disclosed polymers appear to be stable, biocompatible and bioabsorbable, while providing for extended nitric oxide release at therapeutic levels. The invention also encompasses medical devices, such as wound dressings and bandages, which include the polymers and are capable of releasing nitric oxide when in use. These devices may be used to treat a wound, various infections, and dermatological conditions.

The therapeutic efficacy of nitric oxide has been demonstrated for many indications, including wound healing. As wounds are deficient in nitric oxide, its application has been shown to have beneficial effects on wound healing by promoting angiogenesis and tissue remodeling.

Potential Commercial Applications: Competitive Advantages:
Wound healing, infections, and dermatological conditions.   The claimed nitric oxide-releasing polymers are bioabsorbable and release greater amounts of nitric oxide over a greater period of time than other NO-releasing polymers.

Joseph Hrabie (NCI)
Larry Keefer (NCI)

Intellectual Property:
US Application No. 61/672,486
PCT Application No. PCT/US2013/050793

Collaboration Opportunity:

The National Cancer Institute Chemical Biology Laboratory is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize NO-releasing polymers for applications in wound healing. For collaboration opportunities, please contact John Hewes, Ph.D. at Click here to view the NCI collaborative opportunity announcement.

Licensing Contact:
Betty Tong , Ph.D.
NIH Office of Technology Transfer
Phone: 301-594-6565

OTT Reference No: E-157-2012/0

Updated: Feb-19-2013