Nitric Oxide-Releasing Polyvinylpyrrolidone-Based Polymers for Wound Healing and Related Applications

Novel nitric oxide-releasing polyvinylpyrrolidone-based polymers, their compositions, and use in treating wounds. The disclosed polymers appear to be stable, biocompatible and bioabsorbable, while providing for extended nitric oxide release at therapeutic levels. The invention also encompasses medical devices, such as wound dressings and bandages, which include the polymers and are capable of releasing nitric oxide when in use. These devices may be used to treat a wound, various infections, and dermatological conditions.

The therapeutic efficacy of nitric oxide has been demonstrated for many indications, including wound healing. As wounds are deficient in nitric oxide, its application has been shown to have beneficial effects on wound healing by promoting angiogenesis and tissue remodeling.

Potential Commercial Applications: Competitive Advantages:
Wound healing, infections, and dermatological conditions.   The claimed nitric oxide-releasing polymers are bioabsorbable and release greater amounts of nitric oxide over a greater period of time than other NO-releasing polymers.

Joseph Hrabie (NCI)
Larry Keefer (NCI)

Intellectual Property:
US Application No. 61/672,486
PCT Application No. PCT/US2013/050793

Licensing Contact:
Betty Tong , Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325
Rockville , MD 20852
Phone: 301-594-6565
Fax: 301-402-0220

OTT Reference No: E-157-2012/0

Updated: 02/19/2013