Recombinant NIE Antigen from Strongyloides stercoralis
Strongyloides stercoralis is an intestinal nematode endemic that affects an estimated 30 to 100 million people worldwide. Many of these individuals may be asymptomatic for decades. The present invention discloses a NIE recombinant antigen that can be used in improved assays and diagnostics for S. stercoralis infection. The NIE antigen is the only one that is non-cross-reactive with sera from humans with other related filaria infections. The NIE antigen can be utilized as a skin test antigen for immediate hypersensitivity as well as for use in ELISA or other assays.
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Thomas Nutman (NIAID)
Ravi Varatharajalu (NIAID)
Franklin Neva (NIAID)
Research Material – Patent protection is not being pursued for this technology.
Krolewiecki AJ, et al. PMID 20739501
Ramanathan R, et al. PMID 18558872
Ravi V, et al. PMID 15891128
Ravi V, et al. PMID 12467975
Edward (Tedd) Fenn , J.D.
NIH Office of Technology Transfer
OTT Reference No: E-081-2012/0