One (1) breeding pair of the transgenic mouse model of Hutchinson-Gilford Progeria Syndrome and Vascular Abnormalities mice.
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A transgenic mouse model of HGPS has been generated using a bacterial artificial chromosome (BAC) with the G608G mutated form of human LMNA. These mice lack the external phenotype seen in human progeria but have the vascular abnormalities resembling the human syndrome. Specifically the animals show progressive vascular smooth muscle cell loss in large arteries and replacement with proteoglycan and collagen indicating progressive vascular calcification. Animal model for studying HGPS arteriosclerosis and cellular aging.