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| Licensing & Royalties >> Licensing Opportunities >> Abstract Details |
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| Diagnostic Assays and Methods of Use for Detection of Filarial Infection |
Description of Invention:
The effort targeting the mosquito borne neglected tropical disease lymphatic filariasis for elimination through mass drug administration by 2020 will require accurate, cost effective methods for detecting early infections. The World Health Organization-recommended immunochromatographic test detects adult Wuchereria bancrofti (Wb) antigen in blood, but shows variable efficacy due to the complex life cycle of the parasites and cross reactivity with other organisms. This variability may hinder effective lymphatic filariasis elimination efforts. This new technology improves available detection methods through use of an isolated immunoreactive antigen, Wb123, from infective stage larvae (L3) Wb; which results in specific detection early in the infective cycle with reduced cross reactivity. This technology may see wide application in testing and surveillance of lymphatic filariasis as part of the effort to eliminate the disease worldwide.
Applications:
- Diagnostics testing
- Infectious disease monitoring
Advantages:
Improved detection of early stage lymphatic filariasis
Development Status:
Inventors:
Thomas B Nutman (NIAID)
Doran Fink (NIAID)
Joseph Kubofcik (NIAID)
Peter D Burbelo (NIDCR)
Patent Status:
HHS, Reference No. E-281-2010/0
PCT, Application No. PCT/US2011/58561 filed 04 Nov 2011
US, Application No. 13/882,850 filed 01 May 2013
Related Technologies:
PCT, Application No. PCT/US2011/023320 filed 01 Feb 2011, Reference No. E-084-2010/0
US, Application No. 61/410,232 filed 04 Nov 2010, Reference No. E-014-2011/0
US, Application No. 13/575,987 filed 30 Jul 2012, Reference No. E-084-2010/0
Relevant Publication:
- Senbagavalli P, et al. [PMID 21734131]
- Bennuru S, et al. [PMID 21606368]
- Steel C, et al. [PMID 21559422]
- Fink DL, et al. [PMID 20980560]
- Bennuru S, et al. [PMID 20889885]
Collaborative Research Opportunity:
The National Institute of Allergy and Infectious Disease (NIAID) is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize Diagnostic Assays and Methods of Use for Detection of Filarial Infection. For collaboration opportunities, please contact Johanna Schneider, Ph.D. at Schneiderjs@niaid.nih.gov or 301-451-9824.
For Licensing Information Please Contact:
Edward (Tedd) Fenn
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: fennea@mail.nih.gov
Phone: 301-435-5031
Fax: 301-402-0220
Ref No: 2321
Updated: 09/2011
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