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| Licensing & Royalties >> Licensing Opportunities >> Abstract Details |
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| Rapid Molecular Assays for Specific Detection and Quantitation of Loa Loa Microfilaremia |
Description of Invention:
The risk of fatal reactions in some infected individuals administered drug treatments for Loa loa infection, and the lack of accurate, convenient, diagnostics for this infection have thwarted efforts to eradicate the disease. Time consuming, labor intensive and training intensive microscope-based analysis of blood samples is the standard available diagnostic for Loa loa infection. This new assay technology introduces an easy to use, species-specific, highly sensitive, diagnostic that is able to be performed with minimal training. Positive test results may be indicated by an easily visualized color change and this test may be run without the need for expensive equipment such as a thermocycler. Because this test is rapid, cost efficient, labor efficient, accurate, and simple to run and read, it may be readily incorporated into portable point-of-care formats. These attributes make it ideally suited for use in locations where Loa loa infection is endemic. These advantages may lead to this technology becoming the new standard for diagnosis of Loa loa infections and a valuable tool, in control programs, to identify risks for adverse treatment reactions.
Applications:
- Diagnostics testing
- Infectious disease monitoring
Advantages:
Greater speed cost and labor efficiencies, accurate, and simple to run and read and ability to be incorporated into portable point-of-care format, ideally suited for Loa loa endemic regions.
Development Status:
Inventors:
Thomas B Nutman (NIAID)
Doran Fink (NIAID)
Related Technologies:
US, Application No. 61/410,239 filed 04 Nov 2010, Reference No. E-281-2010/0
PCT, Application No. PCT/US2011/023320 filed 01 Feb 2011, Reference No. E-084-2010/0
PCT, Application No. PCT/US2011/58561 filed 04 Nov 2011, Reference No. E-281-2010/0
US, Application No. 13/575,987 filed 30 Jul 2012, Reference No. E-084-2010/0
US, Application No. 13/882,850 filed 01 May 2013, Reference No. E-281-2010/0
Relevant Publication:
- Fink DL, et al. [doi:10.1371/journal.pntd.0001299]
- Klion AD, et al. [PMID 2038361]
Collaborative Research Opportunity:
The National Institute of Allergy and Infectious Disease (NIAID) is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize Rapid Molecular Assays for Specific Detection and Quantitation of Loa Loa Microfilaremia. For collaboration opportunities, please contact Johanna Schneider, Ph.D. at Schneiderjs@niaid.nih.gov or 301-451-9824.
For Licensing Information Please Contact:
Edward (Tedd) Fenn
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: fennea@mail.nih.gov
Phone: 301-435-5031
Fax: 301-402-0220
Ref No: 2320
Updated: 09/2011
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