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| Licensing & Royalties >> Licensing Opportunities >> Abstract Details |
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| Improved Standard for Immune System Recovery Assay |
Description of Invention:
Monitoring an immune system that has been depleted by infection (e.g., HIV), chemotherapy, or progenitor cell transplantation is vital to assessing individual’s recovery status. This technology provides a new plasmid standard to be used as part of the existing TREC assay. This new plasmid has a shorter insert than the commercially available one, which means it now matches the PCR product generated in the qPCR reaction in the TREC assay. Additionally, the new plasmid is easier to grow up than the existing standard.
Applications:
TREC assay for T cell concentration measurements
Advantages:
- The insert of standard plasmid is shorter and directly matches the PCR product generated in the qPCR reaction
- The standard plasmid is easy to grow up
Development Status:
Fully developed
Inventors:
Daniel C Douek (NIAID)
Richard A Koup (NIAID)
Brenna J Hill (NIAID)
Patent Status:
HHS, Reference No. E-067-2011/0
Research Material — Patent protection is not being pursued for this technology.
Relevant Publication:
- Douek DC, et al. [PMID 9872319]
- Douek DC, et al. [PMID 10866444]
For Licensing Information Please Contact:
Cristina Thalhammer-Reyero Ph.D., M.B.A.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325
Room 33,
Rockville, MD 20852
United States
Email: thalhamc@mail.nih.gov
Phone: 301-435-4507
Fax: 301-402-0220
Ref No: 2251
Updated: 04/2013
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