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| Licensing & Royalties >> Licensing Opportunities >> Abstract Details |
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| Therapeutic Approach to Neurodegenerative Disorders Using a TFP5-Peptide |
Description of Invention:
This invention discloses methods for treating neurodegenerative diseases by administering cyclin dependent kinase 5 (Cdk5) inhibitory peptides derived from P35, the activator of Cdk5. Abnormally hyperactive Cdk5 has been shown to be associated with a variety of neurodegenerative disorders. Disclosed in this invention are isolated peptide fragments, pharmaceutical compositions and methods for use of such for treating subjects with a neurodegenerative disease, such as Alzheimer’s disease (AD), Amyotrophic Lateral Sclerosis (ALS) and Parkinson’s disease (PD). An inhibitory fragment, TFP5, disclosed in this invention, has been shown to ameliorate symptoms of AD in disease animal models without any evidence of toxicity. In particular, TFP5 treatment of rat cortical neurons reduced hyperactivation of Cdk5 upon neuronal stress and insults. Following intraperitoneal (ip) injection, TFP5 was capable of crossing the BBB and localizing within the brain where it was found to rescue memory deficits and pathology in a double transgenic mouse (APP/PS1) AD model.
Applications:
Therapeutic developments (AD, PD, ALS)
Advantages:
The products are small peptides that pass the blood brain barrier.
Development Status:
Pre-clinical; some animal data
Inventors:
Harish C Pant (NINDS)
Patent Status:
HHS, Reference No. E-144-2010/0
US, Application No. 61/387,839 filed 29 Sep 2010
US, Application No. 13/249,003 filed 29 Sep 2011
Licensing Status:
Available for licensing.
Collaborative Research Opportunity:
The National Institute of Neurological Disorders and Stroke, Neuronal Cytoskeletal Protein Regulation Section, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize topic of invention or related laboratory interests. Please contact Heather Gunas, J.D., M.P.H., at 301-451-3944 or gunash@mail.nih.gov for more information.
For Licensing Information Please Contact:
Betty Tong Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: tongb@mail.nih.gov
Phone: 301-594-6565
Fax: 301-402-0220
Ref No: 2239
Updated: 03/2011
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