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| Licensing & Royalties >> Licensing Opportunities >> Abstract Details |
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| MEN1, The Gene For Multiple Endocrine Neoplasia Type 1 |
Description of Invention:
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant familial cancer syndrome characterized by occurrence of tumors in parathryroids, enteropancreatic endocrine tissues, the anterior pituitary, and occasionally other sites. The present invention provides an isolated DNA sequence encoding a gene which when mutated in the germline is associated with the development of MEN1. This invention also comprises polyclonal and monoclonal antibodies which selectively bind to menin, the protein encoded by MEN1. In addition, the present invention provides methods for immunological detection of menin in biological samples as well as methods for detecting the presence, alteration, or absence of MEN1 DNA or RNA.
Potential areas of application of this invention include sporadic and familial MEN1 diagnostics using immunoassays and nucleic acid hybridizations, and gene therapy.
Inventors:
Settara C Chandrasekharap (NHGRI)
Lance A Liotta (NCI)
Allen M Spiegel (NIDDK)
Patent Status:
HHS, Reference No. E-094-1997/0
US, , Patent No. 7,358,347, Issued 15 Apr 2008
PCT, Application No. PCT/US98/04258 filed 04 Mar 1998
Relevant Publication:
- SC Chandrasekharappa et al. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 1997 Apr 18;276(5311):404-407. [PubMed abs]
For Licensing Information Please Contact:
Surekha Vathyam Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: vathyams@mail.nih.gov
Phone: 301-435-4076
Fax: 301-402-0220
Ref No: 1745
Updated: 08/1997
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