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| Licensing & Royalties >> Licensing Opportunities >> Abstract Details |
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| Veterinary Influenza Vaccines |
Description of Invention:
Sustained outbreaks of highly pathogenic influenza in animals increase the risk of reassortment and adaption to humans. This technology describes DNA vaccines against influenza serotypes H5N1, H1N1, H3N2, and H3N8 for poultry, swine and equine. Particularly one vaccine, a trivalent combination of H5N1 immunogens, effectively protects against homologous and heterologous challenges. These vaccines can be delivered intramuscularly or through needle-free delivery mechanism.
Applications:
Veterinary influenza vaccine specifically designed for poultry, swine and equine.
Advantages:
- More efficient and versatile than the conventional inactivated whole-virus vaccines
- Can be precisely tailored to target one or more strains of avian, swine or equine outbreaks
- Adaptable to large scale immunization
- Shorter production time than the current egg-based technology
- Noninfectious and safe to manipulate and handle
- Needle-free device delivery elicits robust cellular immune response
Development Status:
Data are available on mice, chicken, swine, and equine.
Inventors:
Gary J Nabel (NIAID)
Zhi-yong Yang (NIAID)
Srinivas Rao (NIAID)
Chih-jen Wei (NIAID)
Wing-pui Kong (NIAID)
Patent Status:
HHS, Reference No. E-050-2008/2
PCT, Application No. PCT/US2009/031329 filed 16 Jan 2009 which published as WO 2009/092038 on 23 July 2009
US, Application No. 12/838,292 filed 16 Jul 2010
Related Technologies:
US, Patent No. 7,094,598, Issued 22 Aug 2006, Reference No. E-241-2001/1
Relevant Publication:
- Rao S, Kong WP, Wei CJ, Yang ZY, Nason M, Styles D, DeTolla LJ, Panda A, Sorrell EM , Song H, Wan H, Ramirez-Nieto GC, Perez D, Nabel GJ. Multivalent HA DNA vaccination protects against highly pathogenic H5N1 avian influenza infection in chickens and mice. PLoS ONE 3(6):e2432. Epub 2008 June 18. [PubMed: 19293944]
- Swine and equine publications are being submitted for review.
Licensing Status:
Available for licensing.
For Licensing Information Please Contact:
Cristina Thalhammer-Reyero Ph.D., M.B.A.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325
Room 33,
Rockville, MD 20852
United States
Email: thalhamc@mail.nih.gov
Phone: 301-435-4507
Fax: 301-402-0220
Ref No: 1731
Updated: 03/2011
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