|
 |
| |
| |
| Licensing & Royalties >> Licensing Opportunities >> Abstract Details |
|
| |
| Poultry Influenza Vaccine |
Description of Invention:
Sustained outbreaks of highly pathogenic avian influenza H5N1 in avian species increase the risk of reassortment and adaptation to humans. The ability to contain its spread in birds would reduce this threat and help maintain the capacity for egg-based vaccine production.
This technology describes DNA vaccines against avian influenza. These vaccines were used to elicit antibodies in animals that were effective against homologous and heterologous H5 challenge studies. One vaccine, a trivalent combination of H5 immunogens, was particularly effective in conferring protection. These vaccines can be delivered intramuscularly or through needle-free delivery mechanism.
Applications:
Avian influenza vaccine specifically designed for poultry and other avian species.
Advantages:
- Protects against homologous and heterologous challenges
- Needle-free delivery elicits robust immune response
Development Status:
Animal (mouse and chicken) data available.
Inventors:
Gary J Nabel (NIAID)
Zhi-yong Yang (NIAID)
Wing-pui Kong (NIAID)
Chih-jen Wei (NIAID)
Srinivas Rao (NIAID)
Patent Status:
HHS, Reference No. E-050-2008/2
PCT, Application No. PCT/US2009/031329 filed 16 Jan 2009
Related Technologies:
US, Patent No. 7,094,598, Issued 22 Aug 2006, Reference No. E-241-2001/1
Relevant Publication:
- S Rao, W-P Kong, C-J Wei, Z-Y Yang, M Nason, D Styles, LJ DeTolla, EM Sorrell, H Song, H Wan, GC Ramirez-Nieto, D Perez, GJ Nabel. Multivalent HA DNA vaccination protects against highly pathogenic H5N1 avian influenza infection in chickens and mice. PLoS ONE 3(6):e2432. Published online 2008 June 18 [doi:10.1371/journal.pone.002432]
Licensing Status:
Available for licensing.
Portfolios:
Infectious Diseases
Infectious Diseases - Vaccines
For Additional Information Please Contact:
Cristina Thalhammer-Reyero Ph.D., M.B.A.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325
Room 33,
Rockville, MD 20852
United States
Email: thalhamc@mail.nih.gov
Phone: 301-435-4507
Fax: 301-402-0220
Ref No: 1731
Updated: 09/2009
|
|
|
|
| |
|
|
|
|