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| Licensing & Royalties >> Licensing Opportunities >> Abstract Details |
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| Transgenic Mouse Model that has Defective Innate and Adaptive Immunity |
Description of Invention:
The present research tool is a transgenic mouse model (C57BL/6 H-2b) that has defective innate and adaptive immunity. The mouse model harbors adaptive immunity cells, but lacks normal cellular responses and has an altered pattern of antibody production. The cells of the innate immune system (NK and NKT cells) are also nearly absent.
The mouse model lacks lymph nodes. The mouse model also lacks the ability to reject autologous, allogeneic, and presumably xenogeneic cells. The mouse model also has a defective antibody production mechanism, making only early antibodies (IgM) and little, if any, mature isotypes (G2a, G2b).
Applications:
- New mouse model to study human tumors.
- New mouse model to study immune function reconstitution.
- New mouse model to study the development of lymph nodes and role of lymph nodes in the disease process.
- Most mouse or human progenitor cells can be transferred to and engraft in the mouse model.
Development Status:
The technology is a research tool.
Inventors:
John R Ortaldo (NCI)
Patent Status:
HHS, Reference No. E-290-2005/0
Research Tool -- patent protection is not being pursued for this technology
Relevant Publication:
- JJ Subleski, VL Hall, TC Back, JR Ortaldo, RH Wiltrout. Enhanced antitumor response by divergent modulation of natural killer and natural killer T cells in the liver. Cancer Res. 2006 Nov 15;66(22):11005-11012. [PubMed abs]
- JR Ortaldo, A Mason, J Willette-Brown, FW Ruscetti, J Wine, T Back, T Stull, EW Bere, L Feigenbaum, R Winkler-Pickett, and HA Young. Modulation of lymphocyte function with inhibitory CD2: Loss of NK and NKT function. Cell Immunol. 2007 Sep;249(1):8-19. [PubMed abs]
Licensing Status:
This technology is not patented. The mouse model will be transferred through a Material Transfer Agreement (for not-for-profit institutions) or through a Biological Materials License (commercial entities).
Licensing Contact for Commercial Entities:
Surekha Vathyam, Ph.D.; 301/435-4076; vathyams@mail.nih.gov
Material Transfer Agreement Contact for Not-For-Profit Institutions:
Kathy Higinbotham; 301/846-5465; higinbok@mail.nih.gov
For Licensing Information Please Contact:
Surekha Vathyam Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: vathyams@mail.nih.gov
Phone: 301-435-4076
Fax: 301-402-0220
Ref No: 1525
Updated: 06/2010
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