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| Licensing & Royalties >> Licensing Opportunities >> Abstract Details |
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| Inhibition of ABC Transporters by Transmembrane Domain Analogs |
Description of Invention:
ABC transporters contain multiple transmembrane domains and are involved in the translocation of a variety of substrates across cell membranes. Upregulation of these transporters contributes to multiple drug resistance in cancer chemotherapy wherein these transporters export chemotherapeutic agents out of cancer cells. The inventors have found that P-glycoprotein and ABCG2 transporter can be effectively inhibited by properly modified peptides corresponding to certain transmembrane domains. This inhibition can be used to overcome drug resistance in resistant tumors.
Applications:
Therapeutics that enhance cancer treatments.
Development Status:
The technology is currently in the pre-clinical stage of development.
Inventors:
Nadya I Tarasova (NCI)
Patent Status:
HHS, Reference No. E-019-2000/2
PCT, Application No. PCT/US00/31817 filed 17 Nov 2000
US, , Patent No. 7,517,849, Issued 14 Apr 2009
HHS, Reference No. E-019-2000/0
HHS, Reference No. E-019-2000/1
HHS, Reference No. E-019-2000/2
Relevant Publication:
- NI Tarasova et al. Transmembrane inhibitors of P-glycoprotein, an ABC transporter. J Med Chem. 2005 Jun 2;48(11):3768-3775. [PubMed abs]
- NI Tarasova et al. Inhibition of G-protein-coupled receptor function by disruption of transmembrane domain interactions. J Biol Chem. 1999 Dec 3;274(49):34911-34915. [PubMed abs]
Licensing Status:
Available for licensing.
Collaborative Research Opportunity:
The National Cancer Institute's Structural Biophysics Laboratory is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize inhibitors of multiple drug resistance proteins. Please contact John D. Hewes, Ph.D. at 301-435-3121 or hewesj@mail.nih.gov for more information.
For Licensing Information Please Contact:
Jennifer Wong
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: wongje@mail.nih.gov
Phone: 301-435-4633
Fax: 301-402-0220
Ref No: 1248
Updated: 05/2007
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