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| Licensing & Royalties >> Licensing Opportunities >> Abstract Details |
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| Monoclonal Antibody to the Protein NCOA6 (also called ASC-2, AIB-3) |
Description of Invention:
The invention relates to monoclonal antibodies that bind to the transcription factor NCOA6 (ASC-2, AIB-3, TRB, TRAP250, NRC). The antibodies have proven successful reagents for Western blotting and for purifying complexes containing NCOA6. The Western blot experiments revealed that NCOA6 is over-expressed in several breast cancer cell lines, and the purification experiments identified a protein complex containing NCOA6 (the ASCOM complex). The monoclonal antibodies may be useful reagents for studying the role of NCOA6 in transcription and for studying the ASCOM complex.
Inventors:
Paul S Meltzer (NHGRI)
Patent Status:
HHS, Reference No. E-168-2005/0
Relevant Publication:
- Young-Hwa Goo et al., "Activating Signal Cointegrator 2 Belongs to a Novel
Steady-State Complex That Contains a Subset of Trithorax Group Proteins,"
Mol. Cell. Biol. (Jan 2003) 23(1):140-149; DOI: 10.1128/MCB.23.1.140-149.2003.
- Soo-Kyung Lee et al., "A Nuclear Factor, ASC-2, as a Cancer-amplified Transcriptional
Coactivator Essential for Ligand-dependent Transactivation by Nuclear Receptors
in Vivo," J. Biol. Chem. (26 Nov 1999) 274(48):34283-34893.
Licensing Status:
In addition to licensing, the technology is available for further development through collaborative research opportunities with the inventors.
For Licensing Information Please Contact:
Whitney Hastings
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: hastingw@mail.nih.gov
Phone: 301-451-7337
Fax: 301-402-0220
Ref No: 1160
Updated: 08/2005
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