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| Licensing & Royalties >> Licensing Opportunities >> Abstract Details |
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| Molecular Encapsulation and Delivery of Alkanes to Living Mammalian Cells for Risk Assessment and Pharmaceutical Applications |
Description of Invention:
A method of encapsulating and delivering alkanes to living cells offers an important tool for studying the toxic, genotoxic, and mitogenic effects of these compounds. The alkane components of mineral paraffin oils are implicated in a number of inflammatory or pathologic conditions, including cancers such as plasmacytomas. In the past it has been difficult to study the effects of mineral oil alkanes, such as pristane, on cells because they are difficult to solubilize and, thus, to deliver to cells. This technique uses cyclodextrins to solubilize and deliver alkanes to cells, tissue, and organs in vitro and in vivo.
Inventors:
Siegfried Janz
Patent Status:
HHS, Reference No. E-193-1990/0
Relevant Publication:
- S Janz, E Shacter, A Herrmann, "Fusion between enveloped viruses and erythrocyte membranes is induced by the isoprenoid alkane pristane (2,6,10,14-tetramethylpentadecane)," Cancer Biochem Biophys 1994 Apr;14(1):1-14.
For Licensing Information Please Contact:
Admin. Licensing Spec-Cancer
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: mb715y@nih.gov
Phone: 301-496-7057
Fax: 301-402-0220
Ref No: 105
Updated: 02/1992
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